Mesangial Cells Initiate Compensatory Tubular Cell Hypertrophy
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چکیده
منابع مشابه
Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF-beta secretion: effect of the immunomodulator AS101 on this process.
The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and the effect of the immunomodulator AS101 on this process. One hundred forty unilateral nephrectomized and sham-operated male Sprague-Dawley rats were treated by AS101 or PBS before and after surgery. The results show that secretion of IL-10 and TGF-beta by mesangial c...
متن کاملMesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF- secretion: effect of the immunomodulator AS101 on this process
Inna Sinuani,* Zhan Averbukh,* Inna Gitelman, Micha J. Rapoport, Judit Sandbank, Michael Albeck, Benjamin Sredni,* and Joshua Weissgarten* Nephrology Division, Assaf Harofeh Medical Center, Zerifin; C.A.I.R. Institute, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan; Department of Molecular Genetics of Development, Ben Gurion University, Beer Sheva; Department of Internal Medicine C, A...
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Previous work showed that uninephrectomized (NPX) rats are more susceptible to the nephropathy induced by some doses of HgCl2 than sham-operated (SHAM) rats. The aim of the present study was to investigate the cytotoxic effects of HgCl2 in proximal tubular (PT) cells isolated from the kidney(s) of both NPX and SHAM rats. The study was designed to test if isolated PT cells that have undergone co...
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Angiotensin II, a potent vasoconstrictor and known growth factor for vascular smooth muscle cells, has been implicated in the development of glomerulosclerosis. Because mesangial cell growth plays a critical role in the glomerulosclerotic process, the objective of this study was to determine the direct effect of long-term (48-hour) angiotensin II treatment on the growth of cultured murine mesan...
متن کاملActivated CD4+ T cells target mesangial antigens and initiate glomerulonephritis.
AIMS The role of kidney infiltrating T cells in the pathology of lupus nephritis is unclear. This study was undertaken to investigate whether CD4+ T cell responses to a surrogate mesangial antigen can initiate glomerulonephritis. METHODS Ovalbumin (OVA) was deposited in the glomerular mesangium of C57BL/6 (B6) mice using anti-α8-integrin immunoliposomes (α8ILs). This was followed by injection...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2010
ISSN: 1421-9670,0250-8095
DOI: 10.1159/000287229